[HTML][HTML] Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer's disease
F Kametani, M Hasegawa - Frontiers in neuroscience, 2018 - frontiersin.org
The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …
Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
[HTML][HTML] PET imaging of tau deposition in the aging human brain
Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive
aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively …
aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively …
On the path to 2025: understanding the Alzheimer's disease continuum
PS Aisen, J Cummings, CR Jack, JC Morris… - Alzheimer's research & …, 2017 - Springer
Basic research advances in recent years have furthered our understanding of the natural
history of Alzheimer's disease (AD). It is now recognized that pathophysiological changes …
history of Alzheimer's disease (AD). It is now recognized that pathophysiological changes …
Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions
Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …
Tau and tauopathies
T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes
Importance Positron emission tomography (PET) may increase the diagnostic accuracy and
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
Increased medial temporal tau positron emission tomography uptake in the absence of amyloid-β positivity
A Costoya-Sánchez, A Moscoso… - JAMA …, 2023 - jamanetwork.com
Importance An increased tau positron emission tomography (PET) signal in the medial
temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β …
temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β …
Diagnostic performance of RO948 F 18 tau positron emission tomography in the differentiation of Alzheimer disease from other neurodegenerative disorders
Importance The diagnostic performance of second-generation tau positron emission
tomographic (PET) tracers is not yet known. Objective To examine the novel tau PET tracer …
tomographic (PET) tracers is not yet known. Objective To examine the novel tau PET tracer …