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Microglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and disease
Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …
derived from the embryonic yolk sac and make their way to the CNS during early …
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …
Complement-mediated synapse loss in Alzheimer's disease: mechanisms and involvement of risk factors
L Wen, D Bi, Y Shen - Trends in Neurosciences, 2024 - cell.com
The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination
Heterozygous mutations in the granulin (GRN) gene, resulting in the haploinsufficiency of
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
Research into the disequilibrium of microglial phenotypes has become an area of intense
focus in neurodegenerative disease as a potential mechanism that contributes to chronic …
focus in neurodegenerative disease as a potential mechanism that contributes to chronic …
Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury
S Wang, MP Weyer, R Hummel… - Journal of …, 2024 - Springer
Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-
inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal …
inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal …
The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness
AL Wang, EA Mambou, AW Kao - Human Molecular Genetics, 2024 - academic.oup.com
Progranulin is an evolutionarily conserved protein that has been implicated in human
neurodevelopmental and neurodegenerative diseases. Human progranulin is comprised of …
neurodevelopmental and neurodegenerative diseases. Human progranulin is comprised of …
Epigenetic regulation of Parkinson's disease risk variant GPNMB cg17274742 methylation by sex and exercise from Taiwan Biobank
YC Chen, YC Liaw, ON Nfor, CH Hsiao… - Frontiers in Aging …, 2023 - frontiersin.org
Background Parkinson's disease (PD) is a complex neurodegenerative disease with an
elusive etiology that involves the interaction between genetic, behavioral, and …
elusive etiology that involves the interaction between genetic, behavioral, and …
Fundamental Neurochemistry Review: Lipids across microglial states
The capacity of immune cells to alter their function based on their metabolism is the basis of
the emerging field of immunometabolism. Microglia are the resident innate immune cells of …
the emerging field of immunometabolism. Microglia are the resident innate immune cells of …
Nicorandil treatment improves survival and spatial learning in aged granulin knockout mice
Mutations in the human granulin (GRN) gene are associated with multiple diseases,
including dementia disorders such as frontotemporal dementia (FTD) and limbic …
including dementia disorders such as frontotemporal dementia (FTD) and limbic …