Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems

MJ Sarmento, M Hof, R Šachl - Frontiers in cell and developmental …, 2020 - frontiersin.org
The plasma membrane is a complex system, consisting of two layers of lipids and proteins
compartmentalized into small structures called nanodomains. Despite the asymmetric …

The fine‐tuning of cell membrane lipid bilayers accentuates their compositional complexity

T Dingjan, AH Futerman - BioEssays, 2021 - Wiley Online Library
Cell membranes are now emerging as finely tuned molecular systems, signifying that re‐
evaluation of our understanding of their structure is essential. Although the idea that cell …

Elastic deformations mediate interaction of the raft boundary with membrane inclusions leading to their effective lateral sorting

KV Pinigin, OV Kondrashov, I Jiménez-Munguía… - Scientific Reports, 2020 - nature.com
Liquid-ordered lipid domains represent a lateral inhomogeneity in cellular membranes.
These domains have elastic and physicochemical properties different from those of the …

Understanding forster resonance energy transfer in the sheet regime with DNA brick-based dye networks

D Mathur, A Samanta, MG Ancona, SA Díaz, Y Kim… - ACS …, 2021 - ACS Publications
Controlling excitonic energy transfer at the molecular level is a key requirement for
transitioning nanophotonics research to viable devices with the main inspiration coming …

Organization of gangliosides into membrane nanodomains

MJ Sarmento, JC Ricardo, M Amaro, R Šachl - FEBS letters, 2020 - Wiley Online Library
Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain
that contains one or more sialic acids. This unique structure endows gangliosides with a …

Biophysical studies of lipid nanodomains using different physical characterization techniques

JJ Kinnun, HL Scott, D Bolmatov, CP Collier… - Biophysical …, 2023 - cell.com
For the past 50 years, evidence for the existence of functional lipid domains has been
steadily accumulating. Although the notion of functional lipid domains, also known as" lipid …

Ordered lipid domains assemble via concerted recruitment of constituents from both membrane leaflets

A Saitov, SA Akimov, TR Galimzyanov, T Glasnov… - Physical review …, 2020 - APS
Lipid rafts serve as anchoring platforms for membrane proteins. Thus far they escaped direct
observation by light microscopy due to their small size. Here we used differently colored …

Preferential protein partitioning in biological membrane with coexisting liquid ordered and liquid disordered phase behavior: underlying design principles

J Bodosa, SS Iyer, A Srivastava - The Journal of Membrane Biology, 2020 - Springer
Several studies now show that certain proteins exhibit selective preference toward liquid
ordered (L _o o) or toward liquid disordered (L _d d) regions of the heterogeneous …

Which Moiety Drives Gangliosides to Form Nanodomains?

D Davidović, M Kukulka, MJ Sarmento… - The Journal of …, 2023 - ACS Publications
Gangliosides are important glycosphingolipids involved in a multitude of physiological
functions. From a physicochemical standpoint, this is related to their ability to self-organize …

The impact of the glycan headgroup on the nanoscopic segregation of gangliosides

MJ Sarmento, MC Owen, JC Ricardo, B Chmelová… - Biophysical …, 2021 - cell.com
Gangliosides form an important class of receptor lipids containing a large oligosaccharide
headgroup whose ability to self-organize within lipid membranes results in the formation of …