Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

In the face of systemic risk factors, certain regions of the arterial vasculature remain relatively
resistant to the development of atherosclerotic lesions. The biomechanically distinct …

Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …

Lung Krüppel-like factor (LKLF/KLF2) is an endothelial transcription factor that is crucially
involved in murine vasculogenesis and is specifically regulated by flow in vitro. We now …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Force production and the propagation of stress and strain within embryos and organisms are
crucial physical processes that direct morphogenesis. In addition, there is mounting …

Objectives: The aim of this study was to decide whether bicuspid aortic valves (BAVs) with
fused right and noncoronary leaflets (RN) and BAVs with fused right and left leaflets (RL) …

Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow.
In endothelial cells (ECs), they function by transducing local blood flow information into …

Mechanical forces are essential contributors to and unavoidable components of cardiac
formation, both inducing and orchestrating local and global molecular and cellular changes …