Are nutraceuticals effective in COVID-19 and post-COVID prevention and treatment?

A Catalano, D Iacopetta, J Ceramella, ACD Maio… - Foods, 2022 - mdpi.com
The beginning of the end or the end of the beginning? After two years mastered by
coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The …

Antimicrobial stewardship using biomarkers: Accumulating evidence for the critically ill

E Kyriazopoulou, EJ Giamarellos-Bourboulis - Antibiotics, 2022 - mdpi.com
This review aims to summarize current progress in the management of critically ill, using
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …

Procalcitonin-guided antibiotic prescription in patients with COVID-19: a multicenter observational cohort study

LM Hessels, E Speksnijder, N Paternotte… - Chest, 2023 - Elsevier
Background Despite the low rate of bacterial coinfection, antibiotics are very commonly
prescribed in hospitalized patients with COVID-19. Research Question Does the use of a …

Procalcitonin and C-reactive protein as diagnostic biomarkers in COVID-19 and Non-COVID-19 sepsis patients: a comparative study

J Shi, Y Zhuo, TQ Wang, CE Lv, LH Yao… - BMC Infectious …, 2024 - Springer
Background This study aimed to assess and compare procalcitonin (PCT) and C-reactive
protein (CRP) levels between COVID-19 and non-COVID-19 sepsis patients. Additionally …

Impact of the COVID-19 Pandemic on the Epidemiology of Bloodstream Infections in Hospitalized Patients—Experience from a 4th Military Clinical Hospital in Poland

N Słabisz, R Dudek-Wicher, P Leśnik, J Majda… - Journal of Clinical …, 2023 - mdpi.com
Bloodstream infections (BSIs) are associated with high mortality and inappropriate or
delayed antimicrobial therapy. The purpose of this study was to investigate the impact of the …

In-hospital antibiotic use for COVID-19: facts and rationales assessed through a mixed-methods study

LE Stoichitoiu, L Pinte, A Ceasovschih… - Journal of Clinical …, 2022 - mdpi.com
It is well known that during the coronavirus disease 2019 (COVID-19) pandemic, antibiotics
were overprescribed. However, less is known regarding the arguments that have led to this …

[HTML][HTML] Proprotein Convertase Subtilisin/Kexin Type 9 Induction in COVID-19 Is Poorly Associated with Disease Severity and Cholesterol Levels

P Mester, P Amend, S Schmid, JJ Wenzel… - Infectious Disease …, 2024 - mdpi.com
SARS-CoV-2 infection was shown to induce proprotein convertase subtilisin/kexin type 9
(PCSK9) plasma levels in sepsis. Here, we investigate the association between serum …

Plasma Insulin-like Growth Factor-Binding Protein-2 of Critically Ill Patients Is Related to Disease Severity and Survival

P Mester, U Räth, L Popp, S Schmid, M Müller… - Biomedicines, 2023 - mdpi.com
Insulin-like growth factor-binding protein (IGFBP)-2 regulates the bioactivity of the anabolic
hormone's insulin-like growth factors, which are decreased in sepsis and contribute to the …

Reduced Reliability of Procalcitonin (PCT) as a Biomarker of Bacterial Superinfection: Concerns about PCT-Driven Antibiotic Stewardship in Critically Ill COVID-19 …

G Ceccarelli, F Alessandri, G Migliara… - Journal of Clinical …, 2023 - mdpi.com
Background: The aim of this study was to assess whether procalcitonin levels is a diagnostic
tool capable of accurately identifying sepsis and ventilator-associated pneumonia (VAP) …

Hematological Parameters and Procalcitonin as Discriminants between Bacterial Pneumonia-Induced Sepsis and Viral Sepsis Secondary to COVID-19: A …

E Moisa, M Dutu, D Corneci, IM Grintescu… - International Journal of …, 2023 - mdpi.com
Bacterial and viral sepsis induce alterations of all hematological parameters and
procalcitonin is used as a biomarker of infection and disease severity. Our aim was to study …