De novo lipogenesis, a hallmark for cancers is required for cellular transformation. Further it
is believed that resistance to apoptosis and epithelial-to-mesenchymal-transition (EMT) …

Aberrant regulation of cholesterol homeostasis is associated with obesity as well as multiple
types of cancer. However, the mechanism behind these is largely missing. Here, we show …

Although the incidence and mortality of lung cancer have decreased significantly in the past
decade, it is still one of the leading causes of death, which greatly impairs people's life and …

Background Lung cancer remains the leading cause of cancer-related death worldwide. The
human PINK1 gene (PTEN induced kinase 1, Park6), an important gene for Parkinson's …

Psoriasis is recognized as a T cell mediated inflammatory hyperproliferative skin disorder.
Several microRNAs (miRNAs) have been implicated in the pathogenesis of psoriasis …

To investigate heterogeneity of endothelial cells (ECs) in the tumor microenvironment and
biomarkers for antitumor angiogenesis therapy, high-purity (> 98%) normal (NECs) and …

We investigated the cytotoxic effect of Pelargonium sidoides extract on Madin–Darby canine
kidney (MDCK) cells. P. sidoides extract decreased the cell viability in a dose dependent …

Idiopathic pulmonary fibrosis (IPF) is a form of chronic and irreversible fibrosing interstitial
pneumonia of unknown etiology. Although antifibrotic treatments have shown a reduction of …

Lung cancer including non-small cell lung cancer (NSCLC) and small cell lung cancer is
one of the most aggressive tumors with high incidence and low survival rate. The typical …

Thiocoumarins and dithiocoumarins are two important classes of sulphurcontaining
heterocyclic compounds, which are bioisosteres of coumarins. Herein, various synthetic …