Tourette syndrome is a chronic neurodevelopmental disorder characterised by motor and
phonic tics that can substantially diminish the quality of life of affected individuals. Evaluating …

Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

In vertebrates, during an early wave of hematopoiesis in the yolk sac between embryonic
day E7. 0 and E9. 0, cells of mesodermal leaflet addressed to macrophage lineage enter in …

Tics are characterized by sudden, rapid, recurrent, nonrhythmic movement or vocalization,
and are the most common movement disorders in children. Their onset is usually in …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

Recent advances have substantially increased the number of genes that are statistically
associated with complex genetic disorders of the CNS such as autism and schizophrenia. It …

Among the four G protein–coupled receptors (H 1–H 4) identified as mediators of the
biologic effects of histamine, the H 3 receptor (H 3 R) is distinguished for its almost exclusive …

Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder
that is characterized by several motor and phonic tics. Tics usually develop before 10 years …

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful
approach to gene discovery in complex neurodevelopmental disorders. We have completed …

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and
abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc) …