Drosophila as a Model Organism

M Yamaguchi, H Yoshida - Drosophila models for human diseases, 2018 - Springer
Drosophila melanogaster has been widely used in classical and modern genetics for more
than 100 years. The history of the Drosophila model in the study of various aspects of life …

ChIP-Atlas 3.0: a data-mining suite to explore chromosome architecture together with large-scale regulome data

Z Zou, T Ohta, S Oki - Nucleic Acids Research, 2024 - academic.oup.com
Abstract ChIP-Atlas (https://chip-atlas. org/) presents a suite of data-mining tools for
analyzing epigenomic landscapes, powered by the comprehensive integration of over 376 …

Long noncoding RNAs as new architects in cancer epigenetics, prognostic biomarkers, and potential therapeutic targets

D Meseure, K Drak Alsibai, A Nicolas… - BioMed research …, 2015 - Wiley Online Library
Recent advances in genome‐wide analysis have revealed that 66% of the genome is
actively transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences …

Genetics on the Fly: A Primer on the Drosophila Model System

KG Hales, CA Korey, AM Larracuente, DM Roberts - Genetics, 2015 - academic.oup.com
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Highly contiguous assemblies of 101 drosophilid genomes

BY Kim, JR Wang, DE Miller, O Barmina, E Delaney… - Elife, 2021 - elifesciences.org
Over 100 years of studies in Drosophila melanogaster and related species in the genus
Drosophila have facilitated key discoveries in genetics, genomics, and evolution. While high …

Illumina TruSeq Synthetic Long-Reads Empower De Novo Assembly and Resolve Complex, Highly-Repetitive Transposable Elements

RC McCoy, RW Taylor, TA Blauwkamp, JL Kelley… - PloS one, 2014 - journals.plos.org
High-throughput DNA sequencing technologies have revolutionized genomic analysis,
including the de novo assembly of whole genomes. Nevertheless, assembly of complex …

Drosophila innate immunity: regional and functional specialization of prophenoloxidases

JP Dudzic, S Kondo, R Ueda, CM Bergman, B Lemaitre - BMC biology, 2015 - Springer
Background The diversification of immune systems during evolution involves the expansion
of particular gene families in given phyla. A better understanding of the metazoan immune …

Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta

MR Kanost, EL Arrese, X Cao, YR Chen… - Insect biochemistry and …, 2016 - Elsevier
Manduca sexta, known as the tobacco hornworm or Carolina sphinx moth, is a lepidopteran
insect that is used extensively as a model system for research in insect biochemistry …

Predicting miRNA-disease association via graph attention learning and multiplex adaptive modality fusion

Z **, M Wang, C Tang, X Zheng, W Zhang… - Computers in Biology …, 2024 - Elsevier
Abstract miRNAs are a class of small non-coding RNA molecules that play important roles in
gene regulation. They are crucial for maintaining normal cellular functions, and …

Sex-and tissue-specific functions of Drosophila doublesex transcription factor target genes

E Clough, E Jimenez, YA Kim, C Whitworth… - Developmental cell, 2014 - cell.com
Primary sex-determination" switches" evolve rapidly, but Doublesex (DSX)-related
transcription factors (DMRTs) act downstream of these switches to control sexual …