CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …

Chemokines are small peptides that are potent activators and chemoattractants for leukocyte
subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7 …

A recently identified chemokine, fractalkine, is a member of the chemokine gene family,
which consists principally of secreted, proinflammatory molecules. Fractalkine is …

Chemokines were originally described as chemotactic cytokines involved in leukocyte
trafficking. Research over the last decade, however, has shown that chemokine receptors …

Monocyte recruitment to the central nervous system (CNS) is a necessary step in the
development of pathologic inflammatory lesions in experimental autoimmune …

Among the chemokine family, fractalkine shows unusual properties: it exists as a membrane‐
bound and soluble protein, and both fractalkine and its receptor CX3CR1 are expressed …

Chemokines are a family of proteins associated with the trafficking of leukocytes in
physiological immune surveillance and inflammatory cell recruitment in host defence. They …

Chemokines–chemotactic cytokines–are small secreted proteins that attract and activate
immune and non-immune cells in vitro and in vivo. It has been suggested that chemokines …

Although chemokines were originally defined as host defense proteins it is now clear that
their repertoire of functions extend well beyond this role. For example chemokines such as …

Chemotactic cytokines (chemokines) have been traditionally defined as small (10–14kDa)
secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are …