Hypertension meets osteoarthritis—revisiting the vascular aetiology hypothesis
Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion
abnormalities and neovascular invasion into the synovium and articular cartilage. In addition …
abnormalities and neovascular invasion into the synovium and articular cartilage. In addition …
[HTML][HTML] Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit
The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …
Weibel Palade bodies: unique secretory organelles of endothelial cells that control blood vessel homeostasis
J Naß, J Terglane, V Gerke - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …
Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage
Background Intracerebral hemorrhage (ICH) has a high morbidity and mortality. The
peripheral immune system and cross-talk between peripheral blood and brain have been …
peripheral immune system and cross-talk between peripheral blood and brain have been …
GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies
M Kat, PE Bürgisser, H Janssen, IM De Cuyper… - Blood …, 2021 - ashpublications.org
Abstract von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized
and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The …
and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The …
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
K Kinghorn, A Gill, A Marvin, R Li, K Quigley, S Singh… - Angiogenesis, 2024 - Springer
Abstract FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper
vessel morphogenesis during vascular development and vessel homeostasis. Although a …
vessel morphogenesis during vascular development and vessel homeostasis. Although a …
Endothelial Colony Forming Cells in the spotlight, insights into the pathophysiology of von Willebrand Disease and rare bleeding disorders.
SNJ Laan, BG Lenderink, JCJ Eikenboom… - Journal of Thrombosis …, 2024 - Elsevier
Endothelial cells deliver a vital contribution to the maintenance of hemostasis by constituting
an anatomical as well as functional barrier between the blood and the rest of the body. Apart …
an anatomical as well as functional barrier between the blood and the rest of the body. Apart …
Recent insights into the regulation of coagulation and thrombosis
X Li, MMS Sim, JP Wood - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
Although procoagulant TF is clearly expressed in the vascular subendothelium, it has also
been proposed that many different cell types express an inactive, encrypted form of TF that …
been proposed that many different cell types express an inactive, encrypted form of TF that …
A new look at an old body: molecular determinants of Weibel-Palade body composition and VWF exocytosis
Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …
[HTML][HTML] Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial …
Weibel-Palade bodies are endothelial secretory organelles that contain von Willebrand
factor, P-selectin and CD63. Release of von Willebrand factor from Weibel-Palade bodies is …
factor, P-selectin and CD63. Release of von Willebrand factor from Weibel-Palade bodies is …