This paper deals with two topics from state and parameter estimation. The first contribution of
this work provides an overview of techniques used for determining which parameters of a …

Computational and mathematical models are key to obtain a system-level understanding of
biological processes, but their limitations have to be clearly defined to allow their proper …

Determining the mathematical dynamics and associated parameter values that should be
used to accurately reflect tumor growth continues to be of interest to mathematical modelers …

This work introduces a comprehensive approach to assess the sensitivity of model outputs to
changes in parameter values, constrained by the combination of prior beliefs and data. This …

Reaction–diffusion models describing the movement, reproduction and death of individuals
within a population are key mathematical modelling tools with widespread applications in …

The key processes in biological and chemical systems are described by networks of
chemical reactions. From molecular biology to biotechnology applications, computational …

The dysfunction of ion channels is a causative factor in a variety of neurological diseases,
thereby defining the implicated channels as key drug targets. The detection of functional …

Inferring parameters for models of biological processes is a current challenge in systems
biology, as is the related problem of comparing competing models that explain the data. In …

Background Accurate estimation of parameters of biochemical models is required to
characterize the dynamics of molecular processes. This problem is intimately linked to …

The last few decades have revealed the living cell to be a crowded spatially heterogeneous
space teeming with biomolecules whose concentrations and activities are governed by …