Dietary fats and prevention of type 2 diabetes

U Risérus, WC Willett, FB Hu - Progress in lipid research, 2009 - Elsevier
Although type 2 diabetes is determined primarily by lifestyle and genes, dietary composition
may affect both its development and complications. Dietary fat is of particular interest …

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

G Musso, R Gambino, M Cassader - Progress in lipid research, 2009 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …

Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism

P Siripoksup, G Cao, AA Cluntun, JA Maschek… - The Journal of clinical …, 2024 - jci.org
Carbohydrates and lipids provide the majority of substrates to fuel mitochondrial oxidative
phosphorylation. Metabolic inflexibility, defined as an impaired ability to switch between …

Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study

B Vessby, M Uusitupa, K Hermansen, G Riccardi… - Diabetologia, 2001 - Springer
Aims/hypothesis. The amount and quality of fat in the diet could be of importance for
development of insulin resistance and related metabolic disorders. Our aim was to …

Skeletal muscle triglyceride levels are inversely related to insulin action

DA Pan, S Lillioja, AD Kriketos, MR Milner, LA Baur… - Diabetes, 1997 - diabetesjournals.org
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG)
correlate with reduced skeletal muscle and whole body insulin action. The aim of this study …

Effects of exercise and diet on chronic disease

CK Roberts, RJ Barnard - Journal of applied physiology, 2005 - journals.physiology.org
Currently, modern chronic diseases, including cardiovascular diseases, Type 2 diabetes,
metabolic syndrome, and cancer, are the leading killers in Westernized society and are …

Dietary fat, insulin sensitivity and the metabolic syndrome

G Riccardi, R Giacco, AA Rivellese - Clinical nutrition, 2004 - Elsevier
Insulin resistance is the pathogenetic link underlying the different metabolic abnormalities
clustering in the metabolic syndrome. It can be induced by different environmental factors …

Diet and risk of type II diabetes: the role of types of fat and carbohydrate

FB Hu, RM Van Dam, S Liu - Diabetologia, 2001 - Springer
Although diet and nutrition are widely believed to play an important part in the development
of Type II (non-insulin-dependent) diabetes mellitus, specific dietary factors have not been …

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in …

G Perseghin, P Scifo, F De Cobelli, E Pagliato… - Diabetes, 1999 - diabetesjournals.org
Insulin resistance is the best prediction factor for the clinical onset of type 2 diabetes. It was
suggested that intramuscular triglyceride store may be a primary pathogenic factor for its …

Diet, nutrition and the prevention of type 2 diabetes

NP Steyn, J Mann, PH Bennett, N Temple… - Public health …, 2004 - cambridge.org
Objectives: The overall objective of this study was to evaluate and provide evidence and
recommendations on current published literature about diet and lifestyle in the prevention of …