Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

Lipidation is a posttranslational modification of proteins that has also found its use in
designing peptide drugs. The presence of a lipid group in peptides modulates their …

In recent years fluorescence quenching has become a popular tool to investigate various
aspects of ligand binding. Unfortunately, various pitfalls are often overlooked in a large …

The global increase in antimicrobial drug resistance has dramatically reduced the
effectiveness of traditional antibiotics. Structurally diverse antibiotics are urgently needed to …

Antimicrobial peptides (AMPs) attack bacterial membranes selectively, killing microbes at
concentrations that cause no toxicity to the host cells. This selectivity is not due to interaction …

Host defense peptides selectively kill bacterial and cancer cells (including those that are
drug-resistant) by perturbing the permeability of their membranes, without being significantly …

Lipopeptide daptomycin is one of the few recently approved antibiotics based on the novel
mechanism of action. Recent advances in synthetic lipopeptides, driven by the biochemical …

Host‐defense peptides (HPDs) are bactericidal and immunomodulatory molecules, part of
the innate immune system of many organisms, including man. They kill bacteria mostly by …

Most antimicrobial peptides exert their activity by interacting with bacterial membranes, thus
perturbing their permeability. They are investigated as a possible solution to the insurgence …

Several bioactive peptides exert their biological function by interacting with cellular
membranes. Structural data on their location inside lipid bilayers are thus essential for a …