Cell death in pancreatic cancer: from pathogenesis to therapy
Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …
The role of p53 in cancer drug resistance and targeted chemotherapy
Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …
Mutant p53 gain-of-function: role in cancer development, progression, and therapeutic approaches
E Alvarado-Ortiz, KG de la Cruz-López… - Frontiers in cell and …, 2021 - frontiersin.org
Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …
Clinical overview of MDM2/X-targeted therapies
MDM2 and MDMX are the primary negative regulators of p53, which under normal
conditions maintain low intracellular levels of p53 by targeting it to the proteasome for rapid …
conditions maintain low intracellular levels of p53 by targeting it to the proteasome for rapid …
Molecular and cellular paradigms of multidrug resistance in cancer
Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …
successful application of cancer therapy. Several anticancer approaches, including …
New therapeutic strategies to treat human cancers expressing mutant p53 proteins
G Blandino, S Di Agostino - Journal of Experimental & Clinical Cancer …, 2018 - Springer
The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …
Small-molecule MMRi62 induces ferroptosis and inhibits metastasis in pancreatic cancer via degradation of ferritin heavy chain and mutant p53
J Li, R Lama, SL Galster, JR Inigo, J Wu… - Molecular cancer …, 2022 - AACR
High frequency of KRAS and TP53 mutations is a unique genetic feature of pancreatic ductal
adenocarcinoma (PDAC). TP53 mutation not only renders PDAC resistance to …
adenocarcinoma (PDAC). TP53 mutation not only renders PDAC resistance to …
Pro-survival autophagy and cancer cell resistance to therapy
Resistance to therapy is one of the prime causes for treatment failure in cancer and recurrent
disease. In recent years, autophagy has emerged as an important cell survival mechanism …
disease. In recent years, autophagy has emerged as an important cell survival mechanism …
[HTML][HTML] Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis
Z Zhou, Y Cheng, Y Jiang, S Liu, M Zhang… - … journal of biological …, 2018 - ncbi.nlm.nih.gov
Since the five-year survival rate is less than 5%, pancreatic ductal adenocarcinoma (PDAC)
remains the 4th cause of cancer-related death. Although PDAC has been repeatedly …
remains the 4th cause of cancer-related death. Although PDAC has been repeatedly …
Cancer stemness: p53 at the wheel
D Ghatak, D Das Ghosh, S Roychoudhury - Frontiers in oncology, 2021 - frontiersin.org
The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …
differentiation to sustain a limited repertoire of stem cells for proper development and …