A large body of evidence has been accumulated that demonstrates dominant effects of Myc
proto-oncoproteins on different aspects of cellular growth. Myc is one of the few proteins that …

The metallothioneins (MT) are small, cysteine-rich heavy metal-binding proteins which
participate in an array of protective stress responses. Although a single essential function of …

Overexpression of plasminogen activator inhibitor-1 (SER-PINE1, PAI-1), the major
physiological inhibitor of pericellular plasmin generation, is a significant causative factor in …

We previously reported that sterol regulation of the rat fatty-acid synthase was lost when the
DNA sequence between− 73 and− 43 of the promoter was deleted from a luciferase reporter …

The MITF transcription factor is a master regulator of melanocyte development and a critical
factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate …

The mRNA cap-binding protein (eukaryotic initiation factor 4E [eIF4E]) binds the m7GpppN
cap on mRNA, thereby initiating translation. eIF4E is essential and rate limiting for protein …

Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte
development and an important oncogene in melanoma. MITF heterodimeric assembly with …

We have determined the distribution of each of the 65,536 DNA sequences that are eight
bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative …

The use of different brain-derived neurotrophic factor (BDNF) gene promoters results in the
differential production of 5′-alternative transcripts, suggesting versatile functions of BDNF …

The crystal structure of a DNA‐binding domain of PHO4 complexed with DNA at 2.8 Å
resolution revealed that the domain folds into a basic–helix–loop–helix (bHLH) motif with a …