Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …

Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from
Erythromycin as Antibacterial Agents Page 1 Send Orders for Reprints to reprints@benthamscience.net …

We report the application of VCD spectroscopy for the characterization of clarithromycin and
erythromycin. We show that the VCD spectra of these large macrolides are distinctly different …

A series of apramycin derivatives was prepared and investigated for antibacterial activity
and the ability to inhibit protein synthesis in cell‐free translation assays. The effect of various …

Macrolide antibiotics, like erythromycin, clarithromycin, and azithromycin, possess anti-
inflammatory properties. These properties are considered fundamental to the efficacy of …

Macrolides, polyketide natural products, and their 15-membered semi-synthetic derivatives
are composed of substituted macrocyclic lactone ring and used primarily as potent …

Inhibition of the enzymatic activity of histone deacetylase (HDAC) is a promising therapeutic
strategy for cancer treatment and several distinct small molecule histone deacetylase …

Neutrophil-dominated inflammatory diseases, like chronic obstructive pulmonary disease,
cystic fibrosis, bronchiectasis, bronchiolitis obliteras syndrome and non-eosinophilic asthma …

Controlling the isomeric impurity in a key raw material is always critical to achieve the
corresponding pure isomer-free targeted active pharmaceutical ingredient (API) in …

Erythromycin, azithromycin, clarithromycin and roxithromycin are antibiotics belonging to the
widely used macrolide group. Their presence in the environment has been much …