Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Reprogramming of cancer metabolism has become increasingly concerned over the last
decade, particularly the reprogramming of glucose metabolism, also known as the" Warburg …

The intention behind the design of a metal complex is quite crucial for its development
towards a particular application. Transition metal complexes have tremendously become …

The leading first‐in‐class ruthenium‐complex BOLD‐100 currently undergoes clinical phase‐
II anticancer evaluation. Recently, BOLD‐100 is identified as anti‐Warburg compound. The …

Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …

Injections of highly cytotoxic or immunomodulating drugs directly into the inoperable tumor is
a procedure that is increasingly applied in the clinic and uses established Pt-based drugs. It …

The COVID-19 pandemic has highlighted an urgent need to discover and test new drugs to
treat patients. Metal-based drugs are known to interact with DNA and/or a variety of proteins …

More than a decade ago, studies on cellular cisplatin accumulation via active membrane
transport established the role of the high affinity copper uptake protein 1 (CTR1) as a main …

In this work we present the synthesis and characterization of six new ruthenium compounds
with general formulae [Ru (L)(dppb)(bipy)] PF 6 and [Ru (L)(dppe) 2] PF 6 where L= salicylic …

Ruthenium complexes are at the forefront of developments in metal-based anticancer drugs,
but many questions remain open regarding their reactivity in biological media, including the …