Graft-versus-host disease is a complication in patients undergoing hematopoietic stem cell
transplantation. Graft-versus-host disease includes acute graft-versus-host disease and …

Allogenic hematopoietic stem cell transplantation (allo-HSCT) represents a potent and
potentially curative treatment for many hematopoietic malignancies and hematologic …

Bruton's Tyrosine Kinase (BTK) and IL-2 Inducible T-cell Kinase (ITK) are enzymes
responsible for the phosphorylation and activation of downstream effectors in the B-cell …

When the genes encoding NF-κB subunits were first isolated, their homology to the
previously identified c-Rel proto-oncogene and its viral homologue v-Rel was clear. This …

Oxidative stress is elevated in the recipients of allogeneic hematopoietic cell transplantation
(allo-HCT) and likely contributes to the development of graft-versus-host disease (GVHD) …

T-bet is a master regulator for IFN-γ production and Th1 differentiation. We evaluated the
roles of T-bet and IFN-γ in T cell responses in acute graft-versus-host disease (GVHD) and …

Preventing unfavorable GVHD without inducing broad suppression of the immune system
presents a major challenge of allogeneic hematopoietic stem cell transplantation (allo …

NF-κB plays a variety of roles in oncogenesis and immunity that may be beneficial for
therapeutic targeting, but strategies to selectively inhibit NF-κB to exert antitumor activity …

Dysregulated NF-κB signaling is critical for lymphomagenesis. The regulation, function, and
clinical relevance of c-Rel/NF-κB activation in diffuse large B-cell lymphoma (DLBCL) have …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective therapeutic
option for many malignant diseases. However, the efficacy of allo-HSCT is limited by the …