[HTML][HTML] Tick-borne encephalitis (TBE): from tick to pathology

DA Worku - Journal of Clinical Medicine, 2023 - mdpi.com
Tick-borne encephalitis (TBE) is a viral arthropod infection, endemic to large parts of Europe
and Asia, and is characterised by neurological involvement, which can range from mild to …

[HTML][HTML] Tick-borne encephalitis virus: A quest for better vaccines against a virus on the rise

M Kubinski, J Beicht, T Gerlach, A Volz, G Sutter… - Vaccines, 2020 - mdpi.com
Tick-borne encephalitis virus (TBEV), a member of the family Flaviviridae, is one of the most
important tick-transmitted viruses in Europe and Asia. Being a neurotropic virus, TBEV …

[HTML][HTML] Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

AJ Zwijnenburg, J Pokharel, R Varnaitė, W Zheng… - Immunity, 2023 - cell.com
T cells differentiate into functionally distinct states upon antigen encounter. These states are
delineated by different cell surface markers for murine and human T cells, which hamper …

Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins

A Aregay, J Slunečko, M Korva, P Bogovic… - npj Vaccines, 2024 - nature.com
Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not
uncommon in endemic areas. The clinical and immunological outcomes have been poorly …

Mechanisms and clinical trials of hepatocellular carcinoma immunotherapy

SL Huang, YM Wang, QY Wang, GG Feng… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC), one of the most common and lethal tumors worldwide, is
usually not diagnosed until the disease is advanced, which results in ineffective intervention …

Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity

A Aregay, J Slunečko, P Bogovic, M Korva… - Emerging Microbes & …, 2024 - Taylor & Francis
Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system
inflammation varying in clinical manifestations and severity. A possible correlation of TBEV …

Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition

T Sandalova, BM Sala, A Achour - Frontiers in Chemistry, 2022 - frontiersin.org
Significant advances in mass-spectroscopy (MS) have made it possible to investigate the
cellular immunopeptidome, a large collection of MHC-associated epitopes presented on the …

T cells in tick-borne flavivirus encephalitis: A review of current paradigms in protection and disease pathology

ET Stone, AK Pinto - Viruses, 2023 - mdpi.com
The family Flaviviridae is comprised of a diverse group of arthropod-borne viruses that are
the etiological agents of globally relevant diseases in humans. Among these, infection with …

Inactivated tick-borne encephalitis vaccine elicits several overlap** waves of T cell response

AL Sycheva, EA Komech, MV Pogorelyy… - Frontiers in …, 2022 - frontiersin.org
The development and implementation of vaccines have been growing exponentially,
remaining one of the major successes of healthcare over the last century. Nowadays, active …

Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination

ET Stone, M Hassert, E Geerling, C Wagner, JD Brien… - Cell reports, 2022 - cell.com
Powassan virus (POWV) is a tick-borne pathogen for which humans are an incidental host.
POWV infection can be fatal or result in long-term neurological sequelae; however, there are …