Reduction in saturated fat intake for cardiovascular disease
L Hooper, N Martin, OF Jimoh, C Kirk… - Cochrane database …, 2020 - cochranelibrary.com
Background Reducing saturated fat reduces serum cholesterol, but effects on other
intermediate outcomes may be less clear. Additionally, it is unclear whether the energy from …
intermediate outcomes may be less clear. Additionally, it is unclear whether the energy from …
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of
clinical risk factors and BMD provide higher specificity and sensitivity than either alone …
clinical risk factors and BMD provide higher specificity and sensitivity than either alone …
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial.
ContextDespite decades of use and considerable research, the role of estrogen alone in
preventing chronic diseases in postmenopausal women remains uncertain. ObjectiveTo …
preventing chronic diseases in postmenopausal women remains uncertain. ObjectiveTo …
Somatic mutations precede acute myeloid leukemia years before diagnosis
P Desai, N Mencia-Trinchant, O Savenkov, MS Simon… - Nature medicine, 2018 - nature.com
The pattern of somatic mutations observed at diagnosis of acute myeloid leukemia (AML)
has been well-characterized. However, the premalignant mutational landscape of AML and …
has been well-characterized. However, the premalignant mutational landscape of AML and …
Smoking and mortality—beyond established causes
Background Mortality among current smokers is 2 to 3 times as high as that among persons
who never smoked. Most of this excess mortality is believed to be explained by 21 common …
who never smoked. Most of this excess mortality is believed to be explained by 21 common …
Association of menopausal hormone therapy with breast cancer incidence and mortality during long-term follow-up of the women's health initiative randomized clinical …
RT Chlebowski, GL Anderson, AK Aragaki… - Jama, 2020 - jamanetwork.com
Importance The influence of menopausal hormone therapy on breast cancer remains
unsettled with discordant findings from observational studies and randomized clinical trials …
unsettled with discordant findings from observational studies and randomized clinical trials …
50-year trends in smoking-related mortality in the United States
MJ Thun, BD Carter, D Feskanich… - … England Journal of …, 2013 - Mass Medical Soc
Background The disease risks from cigarette smoking increased in the United States over
most of the 20th century, first among male smokers and later among female smokers …
most of the 20th century, first among male smokers and later among female smokers …
[HTML][HTML] The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
… -6 Receptor Mendelian Randomisation Analysis (IL6R … - The Lancet, 2012 - Elsevier
BACKGROUND: A high circulating concentration of interleukin 6 is associated with
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …
Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the women's health initiative randomized clinical trials
ML Neuhouser, AK Aragaki, RL Prentice… - JAMA …, 2015 - jamanetwork.com
Importance More than two-thirds of US women are overweight or obese, placing them at
increased risk for postmenopausal breast cancer. Objective To investigate in this secondary …
increased risk for postmenopausal breast cancer. Objective To investigate in this secondary …
[HTML][HTML] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …