One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …

The study of superconductivity in compressed hydrides is of great interest due to
measurements of high critical temperatures (T c) in the vicinity of room temperature …

Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias
with poor prognosis. Current treatment options are of limited effectiveness; thus, there is a …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

The histone H3-lysine 27 (H3K27) methyltransferase EZH2 plays a critical role in regulating
gene expression, and its aberrant activity is linked to the onset and progression of cancer …

S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of
methionine and adenosine. As the second largest cofactor in the human body, its major …

Among epigenetic “writers”,“readers”, and “erasers”, the lysine methyltransferases G9a and
GLP, which catalyze mono-and dimethylation of histone H3 lysine 9 (H3K9me2) and …