Lysine dioxygenase (KDO) is an important enzyme in human physiology involved in
bioprocesses that trigger collagen cross-linking and blood pressure control. There are …

Enzymes turnover substrates into products with amazing efficiency and selectivity and as
such have great potential for use in biotechnology and pharmaceutical applications …

The naphthyridinomycin biosynthesis enzyme NapI selectively performs the desaturation of
a free l-arginine amino acid at the C4–C5 bond as part of its antibiotic biosynthesis reaction …

Many enzymes in nature utilize a free arginine (L-Arg) amino acid to initiate the biosynthesis
of natural products. Examples include nitric oxide synthases, which generate NO from L-Arg …

Despite extensive studies, how carrier-protein-independent BesD dictates the reaction
toward thermodynamically unfavored halogenation is still elusive. Here, we investigated the …

A catalytic system for intramolecular C (sp2)–H and C (sp3)–H amination of substituted
tetrazolopyridines has been successfully developed. The amination reactions are developed …

Nonheme Fe (II) and 2-oxoglutarate (2OG)-dependent histone lysine demethylases 2A
(KDM2A) catalyze the demethylation of the mono-or dimethylated lysine 36 residue in the …

Flavodiiron proteins possess reductive scavenging properties toward dioxygen and/or nitric
oxide in various microorganisms. Among them, the Desulfovibrio gigas flavodiiron protein …

The nonheme iron dioxygenase deoxypodophyllotoxin synthase performs an oxidative ring‐
closure reaction as part of natural product synthesis in plants. How the enzyme enables the …

Ethylene-forming enzyme (EFE) is an iron (II)-dependent dioxygenase that fragments 2-
oxoglutarate (2OG) to ethylene (from C3 and C4) and 3 equivs of carbon dioxide (from C1 …