Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …

Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues.
However, a deep understanding of skeletal development is required in order to model this …

During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …

The segmented body plan of vertebrates is established during somitogenesis, a well-studied
process in model organisms; however, the details of this process in humans remain largely …

The vertebrate body displays a segmental organization that is most conspicuous in the
periodic organization of the vertebral column and peripheral nerves. This metameric …

Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …

Although mechanisms of embryonic development are similar between mice and humans,
the time scale is generally slower in humans. To investigate these interspecies differences in …

Differential speeds in biochemical reactions have been proposed to be responsible for the
differences in developmental tempo between mice and humans. However, the underlying …

Axial development of mammals involves coordinated morphogenetic events, including axial
elongation, somitogenesis, and neural tube formation. To gain insight into the signals …

The developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly
recognized as a major determinant for regional susceptibility or resistance to vascular …