Consecutive multicomponent reactions for the synthesis of complex molecules
S Zhi, X Ma, W Zhang - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction
centers are conducted in one pot and with a single operational step. This synthetic method …
centers are conducted in one pot and with a single operational step. This synthetic method …
Multicomponent reaction design in the quest for molecular complexity and diversity
E Ruijter, R Scheffelaar… - Angewandte Chemie …, 2011 - Wiley Online Library
Multicomponent reactions have become increasingly popular as tools for the rapid
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …
Higher-order multicomponent reactions: beyond four reactants
S Brauch, SS van Berkel, B Westermann - Chemical Society Reviews, 2013 - pubs.rsc.org
Multicomponent reactions (MCRs) are by far the most successful class of reactions leading
to high structural diversity and molecular complexity through a single transformation. As part …
to high structural diversity and molecular complexity through a single transformation. As part …
Recent developments in isocyanide based multicomponent reactions in applied chemistry
A Dömling - Chemical reviews, 2006 - ACS Publications
Multicomponent reactions (MCRs) are generally defined as reactions where more than two
staring materials react to form a product, incorporating essentially all of the atoms of the …
staring materials react to form a product, incorporating essentially all of the atoms of the …
Multicomponent reactions, union of MCRs and beyond
T Zarganes‐Tzitzikas, AL Chandgude… - The Chemical …, 2015 - Wiley Online Library
Multicomponent reactions (MCRs), which are located between one‐and two‐component
and polymerization reactions, provide a number of valuable conceptual and synthetic …
and polymerization reactions, provide a number of valuable conceptual and synthetic …
Isocyanoacetate derivatives: synthesis, reactivity, and application
Isocyanide (isonitrile) chemistry began in 1859 when Lieke obtained the first compound of
this type. 1 In 1958, isocyanides became generally available by dehydration of formamides …
this type. 1 In 1958, isocyanides became generally available by dehydration of formamides …
Mehrkomponentenreaktionen als Weg zu molekularer Komplexität und Diversität
E Ruijter, R Scheffelaar, RVA Orru - Angewandte Chemie, 2011 - Wiley Online Library
Mehrkomponentenreaktionen haben sich zu sehr populären Hilfsmitteln für die schnelle
Erzeugung von Bibliotheken niedermolekularer organischer Verbindungen entwickelt. Um …
Erzeugung von Bibliotheken niedermolekularer organischer Verbindungen entwickelt. Um …
Access to molecular complexity. Multicomponent reactions involving five or more components
VG Nenajdenko - Russian Chemical Reviews, 2020 - iopscience.iop.org
The evaluation of the significance of a chemical transformation addresses many factors,
including such important characteristics as the number of chemical bonds formed in one …
including such important characteristics as the number of chemical bonds formed in one …
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ-and δ-lactams via a ' …
CC Musonda, J Gut, PJ Rosenthal, V Yardley… - Bioorganic & medicinal …, 2006 - Elsevier
A parallel synthesis of a new series of 4-aminoquinoline γ-and δ-lactams synthesized via the
Ugi 3-component 4-centre multicomponent reaction is described. The basicity of the …
Ugi 3-component 4-centre multicomponent reaction is described. The basicity of the …
On the industrial applications of MCRs: Molecular diversity in drug discovery and generic drug synthesis
C Kalinski, M Umkehrer, L Weber, J Kolb, C Burdack… - Molecular …, 2010 - Springer
During the last decades, multicomponent chemistry has gained much attention in
pharmaceutical research, especially in the context of lead finding and optimization. Here, in …
pharmaceutical research, especially in the context of lead finding and optimization. Here, in …