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Young-onset colorectal cancer
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …
cancer but remains underdiagnosed. Large prospective observational studies have recently …
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and …
Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …
30% of the population in the UK have a family history of CRC. The quantification of an …
Milestones of Lynch syndrome: 1895–2015
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome …
Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have
been subject to bias, partly through reliance on retrospective studies. We sought to establish …
been subject to bias, partly through reliance on retrospective studies. We sought to establish …
ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes
This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
Microsatellite instability in colorectal cancer
Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome
V Bonadona, B Bonaïti, S Olschwang, S Grandjouan… - Jama, 2011 - jamanetwork.com
Context Providing accurate estimates of cancer risks is a major challenge in the clinical
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …
Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to
assist health care providers with the appropriate provision of genetic testing and …
assist health care providers with the appropriate provision of genetic testing and …