Anti-inflammatory regulatory T cells have lately attracted attention as part of the immune
response to Mycobacterium tuberculosis infection, where they counterbalance the protective …

Regulatory T-cells (Tregs) act at the interface of host and pathogen interactions in human
infectious diseases. Tregs are induced by a wide range of pathogens, but distinct effects of …

Tuberculosis (TB) is primarily associated with decline in immune health status. As gut
microbiome (GM) is implicated in the regulation of host immunity and metabolism, here we …

It is a commonly held belief that infiltration of immune cells into tumor tissues and direct
physical contact between tumor cells and infiltrated immune cells is associated with physical …

Objectives Immune checkpoint pathways regulate optimal host immune responses against
transformed cells, induce immunological memory, and limit tissue pathology. Conversely …

Background. Overexpression of programmed death 1 (PD-1) receptor is thought to inhibit the
effector T-cell response in human tuberculosis. However, the precise mechanism of such …

By attenuating T-cell activation, immune checkpoints (ICs) limit optimal anti-tumour
responses and IC inhibition (ICI) has emerged as a new therapy for a broad range of …

Cigarette smoke (CS) exposure is a key risk factor for both active and latent tuberculosis
(TB). It is associated with delayed diagnosis, more severe disease progression …

Abstract Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging
due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the …

Objective: To explore the therapeutic effects of early enteral nutrition (EEN) on patients with
sepsis on mechanical ventilation. Methods: Patients with sepsis on mechanical ventilation in …