Over the past few years, the field of regulated cell death continues to expand and novel
mechanisms that orchestrate multiple regulated cell death pathways are being unveiled …

Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and
include keratin 7 (K7), K8, K18–K20, and K23. Genetically engineered mice that lack SEKs …

Purpose: We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in
ovarian cancer via abrogation of a tumor-promoting cytokine network. Experimental Design …

Background Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for
patients with advanced biliary tract cancer; expression of VEGF and its receptors is …

The emphasis in cancer drug development has shifted from cytotoxic, non-specific
chemotherapies to molecularly targeted, rationally designed drugs promising greater …

Serological cell death biomarkers and circulating tumor cells (CTCs) have potential uses as
tools for pharmacodynamic blood-based assays and their subsequent application to early …

BACKGROUND & AIMS: Predicting the probability of patients with acute liver failure (ALF) to
recover spontaneously is of major clinical importance. As apoptotic and necrotic cell death …

Highly sensitive detection of proteins is essential to biomedical research as well as clinical
diagnosis. However, so far most detection methods rely on antibody-based assays and are …

Clinical development of new anticancer drugs can be compromised by a lack of qualified
biomarkers. An indispensable component to successful biomarker qualification is assay …

The tumor necrosis factor (TNF) superfamily member TNF-related apoptosis-inducing ligand
(TRAIL) induces apoptosis in cancer cells via death receptor (DR) activation with little toxicity …