Mitochondrial membrane permeabilization in cell death
Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
PS Brookes, Y Yoon, JL Robotham… - … of Physiology-Cell …, 2004 - journals.physiology.org
The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP
generation. Calcium is a key regulator of mitochondrial function and acts at several levels …
generation. Calcium is a key regulator of mitochondrial function and acts at several levels …
The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
[HTML][HTML] The endoplasmic reticulum–mitochondria connection: one touch, multiple functions
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a
characteristic “network structure” that facilitates the formation of interorganellar connections …
characteristic “network structure” that facilitates the formation of interorganellar connections …
[HTML][HTML] Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis
HA Kalpage, V Bazylianska, MA Recanati… - The FASEB …, 2018 - pmc.ncbi.nlm.nih.gov
Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …
Multifunctional Cytochrome c: Learning New Tricks from an Old Dog
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease involving aggregation
of misfolded proteins inside the neuron causing prolonged cellular stress. The …
of misfolded proteins inside the neuron causing prolonged cellular stress. The …
Mitophagy in cerebral ischemia and ischemia/reperfusion injury
L Shen, Q Gan, Y Yang, C Reis, Z Zhang… - Frontiers in Aging …, 2021 - frontiersin.org
Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. In
recent years, reperfusion treatments based on thrombolytic and thrombectomy are major …
recent years, reperfusion treatments based on thrombolytic and thrombectomy are major …
Role of the unfolded protein response in cell death
R Kim, M Emi, K Tanabe, S Murakami - Apoptosis, 2006 - Springer
Unfolded protein response (UPR) is an important genomic response to endoplasmic
reticulum (ER) stress. The ER chaperones, GRP78 and Gadd153, play critical roles in cell …
reticulum (ER) stress. The ER chaperones, GRP78 and Gadd153, play critical roles in cell …
HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim
P Castellano, L Prevedel, EA Eugenin - Scientific reports, 2017 - nature.com
While HIV kills most of the cells it infects, a small number of infected cells survive and
become latent viral reservoirs, posing a significant barrier to HIV eradication. However, the …
become latent viral reservoirs, posing a significant barrier to HIV eradication. However, the …