Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Physical exercise as an epigenetic modulator of brain plasticity and cognition
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …
function, the effects of which can last for considerable time. An emerging line of scientific …
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …
However, whether platelet factors modulate cognition, a highly valued and central …
MeCP2 links heterochromatin condensates and neurodevelopmental disease
Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …
heterochromatin, which is crucial for chromosome maintenance and transcriptional …
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
Probing gene function in the mammalian brain can be greatly assisted with methods to
manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short …
manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short …
DNA methylation in mammals
E Li, Y Zhang - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …
involved in various biological processes including the silencing of transposable elements …
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …
complex genetic architectures but overlap** behavioral phenotypes, which suggests …
The epigenome and transcriptional dynamics of fruit ripening
J Giovannoni, C Nguyen, B Ampofo… - Annual Review of …, 2017 - annualreviews.org
Fruit has evolved myriad forms that facilitate seed dispersal in varied environmental and
ecological contexts. Because fleshy fruits become attractive and nutritious to seed …
ecological contexts. Because fleshy fruits become attractive and nutritious to seed …
Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder
with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been …
with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been …
Autism risk factors: genes, environment, and gene-environment interactions
The aim of this review is to summarize the key findings from genetic and epidemiological
research, which show that autism is a complex disorder resulting from the combination of …
research, which show that autism is a complex disorder resulting from the combination of …