Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Physical exercise as an epigenetic modulator of brain plasticity and cognition

J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

C Park, O Hahn, S Gupta, AJ Moreno, F Marino, B Kedir… - Nature aging, 2023 - nature.com
Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

MeCP2 links heterochromatin condensates and neurodevelopmental disease

CH Li, EL Coffey, A Dall'Agnese, NM Hannett, X Tang… - Nature, 2020 - nature.com
Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

L Swiech, M Heidenreich, A Banerjee, N Habib… - Nature …, 2015 - nature.com
Probing gene function in the mammalian brain can be greatly assisted with methods to
manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short …

DNA methylation in mammals

E Li, Y Zhang - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …

The epigenome and transcriptional dynamics of fruit ripening

J Giovannoni, C Nguyen, B Ampofo… - Annual Review of …, 2017 - annualreviews.org
Fruit has evolved myriad forms that facilitate seed dispersal in varied environmental and
ecological contexts. Because fleshy fruits become attractive and nutritious to seed …

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

HW Gabel, B Kinde, H Stroud, CS Gilbert, DA Harmin… - Nature, 2015 - nature.com
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder
with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been …

Autism risk factors: genes, environment, and gene-environment interactions

P Chaste, M Leboyer - Dialogues in clinical neuroscience, 2012 - Taylor & Francis
The aim of this review is to summarize the key findings from genetic and epidemiological
research, which show that autism is a complex disorder resulting from the combination of …