Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Amelogenesis imperfecta; genes, proteins, and pathways

CEL Smith, JA Poulter, A Antanaviciute… - Frontiers in …, 2017 - frontiersin.org
Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions
characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft …

A genomics approach reveals insights into the importance of gene losses for mammalian adaptations

V Sharma, N Hecker, JG Roscito, L Foerster… - Nature …, 2018 - nature.com
Identifying the genomic changes that underlie phenotypic adaptations is a key challenge in
evolutionary biology and genomics. Loss of protein-coding genes is one type of genomic …

Amelogenesis imperfecta: Next-generation sequencing sheds light on Witkop's classification

A Bloch-Zupan, T Rey, A Jimenez-Armijo… - Frontiers in …, 2023 - frontiersin.org
Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …

Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders

M de La Dure‐Molla, BP Fournier… - American Journal of …, 2019 - Wiley Online Library
Dental anomalies occur frequently in a number of genetic disorders and act as major signs
in diagnosing these disorders. We present definitions of the most common dental signs and …

Enamel phenotypes: genetic and environmental determinants

JT Wright - Genes, 2023 - mdpi.com
Dental enamel is a specialized tissue that has adapted over millions of years of evolution to
enhance the survival of a variety of species. In humans, enamel evolved to form the exterior …

Antioxidant, anti-inflammatory, and anti-apoptotic effects of genkwanin against aflatoxin B1-induced testicular toxicity

MU Ijaz, A Ishtiaq, A Tahir, MA Alvi, A Rafique… - Toxicology and Applied …, 2023 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) is the most hazardous aflatoxin that causes significant
damage to the male reproductive system. Genkwanin (GNK) is a bioactive flavonoid that …

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

SE Vazquez, EMN Ferré, DW Scheel, S Sunshine… - Elife, 2020 - elifesciences.org
The identification of autoantigens remains a critical challenge for understanding and treating
autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare …

Map** the tooth enamel proteome and amelogenin phosphorylation onto mineralizing porcine tooth crowns

DR Green, F Schulte, KH Lee, MK Pugach… - Frontiers in …, 2019 - frontiersin.org
Tooth enamel forms in an ephemeral protein matrix where changes in protein abundance,
composition and posttranslational modifications are critical to achieve healthy enamel …

Molecular evolutionary analyses of tooth genes support sequential loss of enamel and teeth in baleen whales (Mysticeti)

JG Randall, J Gatesy, MS Springer - Molecular Phylogenetics and …, 2022 - Elsevier
The loss of teeth and evolution of baleen racks in Mysticeti was a profound transformation
that permitted baleen whales to radiate and diversify into a previously underutilized …