The hallmark of nucleophilic phosphine catalysis is the initial nucleophilic addition of a
phosphine to an electrophilic starting material, producing a reactive zwitterionic …

In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable
assembled a list of key green chemistry research areas to both identify transformations that …

The present review “Iron Catalysis in Organic Synthesis” covers the literature until the end of
June 2014 and represents a comprehensive update of a previous article published by Bolm …

Nucleophilic substitution reactions of alcohols are among the most fundamental and
strategically important transformations in organic chemistry. For over half a century, these …

The Mitsunobu reaction was first described almost fifty years ago and has enjoyed immense
popularity since its inception. The purpose of this review is to focus on the more recent …

Process mass intensity (PMI) is a key mass-based metric to evaluate the green credentials of
an individual or sequence of reactions during process and chemical development. The …

The classic chemical Mitsunobu reaction suffers from the need of excess alcohol activation
reagents and the generation of significant by‐products. Efforts to overcome these limitations …

Conjugated polymers have a long history of exploration and use in organic solar cells, and
over the last twenty‐five years, marked increases in the solar cell efficiency have been …

The Mitsunobu reaction is widely regarded as the pre-eminent method for performing
nucleophilic substitutions of alcohols with inversion of configuration. However, its …