In silico clinical trials: how computer simulation will transform the biomedical industry
The term 'in silico clinical trials indicates the use of individualised computer simulation in the
development or regulatory evaluation of a medicinal product, medical device, or medical …
development or regulatory evaluation of a medicinal product, medical device, or medical …
Biomechanics of immature human cortical bone: A systematic review
The whole bone geometry, microstructure, and mechanical properties of mature human
bone are widely reported; however, immature bone (0–18 years) has not been similarly …
bone are widely reported; however, immature bone (0–18 years) has not been similarly …
Material and structural modeling aspects of brain tissue deformation under dynamic loads
The aim of this work was to assess the numerous approaches to structural and material
modeling of brain tissue under dynamic loading conditions. The current technological …
modeling of brain tissue under dynamic loading conditions. The current technological …
[HTML][HTML] Simulated effects of surgical corrections on bone-implant micromotion and implant stresses in paediatric proximal femoral osteotomy
Background and objective Proximal femoral osteotomy (PFO) is a surgical intervention,
typically performed on paediatric population, that aims to correct femoral deformities caused …
typically performed on paediatric population, that aims to correct femoral deformities caused …
Does orthodontic treatment affect the alveolar bone density?
Few studies involving human participants have been conducted to investigate the effect of
orthodontic treatment on alveolar bone density around the teeth. Our previous study …
orthodontic treatment on alveolar bone density around the teeth. Our previous study …
Effect of different constraining boundary conditions on simulated femoral stresses and strains during gait
Finite element analysis (FEA) is commonly used in orthopaedic research to estimate
localised tissue stresses and strains. A variety of boundary conditions have been proposed …
localised tissue stresses and strains. A variety of boundary conditions have been proposed …
Fixation release and the bone bandaid: A new bone fixation device paradigm
The current gold standard of care for mandibular segmental defeat reconstruction is the use
of Ti-6Al-4V immobilization hardware and fibular double barrel graft. This method is often …
of Ti-6Al-4V immobilization hardware and fibular double barrel graft. This method is often …
Investigating the mechanical response of paediatric bone under bending and torsion using finite element analysis
Fractures of bone account 25% of all paediatric injuries (Cooper et al. in J Bone Miner Res
19: 1976–1981, 2004. https://doi. org/10.1359/JBMR. 040902). These can be broadly …
19: 1976–1981, 2004. https://doi. org/10.1359/JBMR. 040902). These can be broadly …
[HTML][HTML] Evaluation of Boundary Conditions for Predicting Femoral Bone-Implant Mechanics During Gait in the Absence of Comprehensive Medical Imaging
Finite element analysis (FEA) is nowadays a pivotal tool in orthopaedic research for
personalized virtual surgery planning. Despite its widespread use, a comprehensive …
personalized virtual surgery planning. Despite its widespread use, a comprehensive …
Biomechanics of the classic metaphyseal lesion: finite element analysis
Background The classic metaphyseal lesion (CML) is strongly associated with infant abuse,
but the biomechanics responsible for this injury have not been rigorously studied …
but the biomechanics responsible for this injury have not been rigorously studied …