Gliomas are the most common primary intracranial tumor, representing 81% of malignant
brain tumors. Although relatively rare, they cause significant mortality and morbidity …

DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …

It is generally accepted that glioma develops through accumulation of genetic alterations.
We hypothesized that polymorphisms of candidate genes involved in the DNA repair …

Genomic instability is a common hallmark of human tumours. As a carrier of genetic
information, DNA is constantly threatened by various damaging factors that, if not repaired in …

In gliomas, germline gene alterations play a significant role during malignant transformation
of progenitor glial cells, at least for families with occurrence of multiple cancers or with …

Glioblastoma is the most common and highest-grade brain tumor, causing over 10,000
deaths each year in the US alone. Given the resistance of this tumor to standard surgery …

Although the etiology of primary brain tumors is largely unknown, prior studies suggest that
DNA repair polymorphisms may influence risk of glioma. Altered DNA repair is also likely to …

Although primary brain tumors (PBTs) are generally considered to be a multifactorial
disorder, understanding the genetic basis and etiology of the disease is essential for PBT …

Leukocyte telomere length is widely considered a biomarker of human age and in many
studies indicative of health or disease. We have obtained quantitative estimates of telomere …

A pooled analysis was conducted to examine the association between select variants in
DNA repair genes and glioblastoma multiforme, the most common and deadliest form of …