NF-κB was first discovered and characterized 25 years ago as a key regulator of inducible
gene expression in the immune system. Thus, it is not surprising that the clearest biological …

Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …

The topic of immunity to fungal infections is of interest to a wide range of disciplines, from
microbiology to immunology. It is of particular interest in terms of therapy of HIV-infected …

Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Toll-like receptors (TLRs) are transmembrane proteins that detect invading pathogens by
binding conserved, microbially derived molecules and that induce signaling cascades for …

Over the last decade, invasive fungal infections have emerged as a growing threat to human
health worldwide and novel treatment strategies are urgently needed. In this context …

Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

Airway tolerance is the usual outcome of inhalation of harmless antigens. Although T cell
deletion and anergy are likely components of tolerogenic mechanisms in the lung …

miRNA-146a, a single-stranded, non-coding RNA molecule, has emerged as a valuable
diagnostic and prognostic biomarker for numerous pathological conditions. Its primary …