Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

De novo drug design aims to generate molecules from scratch that possess specific
chemical and pharmacological properties. We present a computational approach utilizing …

Nuclear receptors (NRs) regulate transcription in response to ligand binding and NR
modulation allows pharmacological control of gene expression. Although some NRs are …

Nuclear receptor related 1 (Nurr1) is a neuroprotective transcription factor and an emerging
target in neurodegenerative diseases. Despite strong evidence for a role in Parkinson's and …

Instances of artificial intelligence equip medicinal chemistry with innovative tools for
molecular design and lead discovery. Here we describe a deep recurrent neural network for …

The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple
metabolic processes. Modulation of FXR is desired to overcome several metabolic …

Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by
accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health …

Farnesoid X receptor (FXR) has emerged as a promising therapeutic target for nonalcoholic
steatohepatitis (NASH) because of its tightly interwoven relationship with bile acid …

Vitamin E exhibits pharmacological effects beyond established antioxidant activity
suggesting involvement of unidentified mechanisms. Here, we characterize endogenously …

The ligand-activated transcription factors Nur77, Nurr1, and NOR-1 forming the NR4A family
of nuclear receptors are considered as potential targets in various pathologies, including …