Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …

In antimalarial drug development research, overcoming drug resistance has been a major
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …

In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …

4-Phenyl-3-[2-(phenylamino) ethyl]-1 H-1, 2, 4-triazole-5 (4 H)-thione was used as a starting
compound for the synthesis of the corresponding 1, 2, 4-triazol-3-ylthioacetohydrazide …

Sixteen isatin-based hydrazone derivatives (IS1–IS16) were synthesized and assessed for
their ability to inhibit monoamine oxidases (MAOs). All the molecules showed improved …

We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and
Q8a–h), in connection with our research interest in develo** novel isatin-bearing anti …

Despite rapid advances in drug accessibility for diagnosis and treatment, breast cancer
remains a common malignancy among women across the world due to the inadequacy of …

Human health is experiencing several obstacles in the modern medical era, particularly
cancer. As a result, the cancer therapeutic arsenal should be continually expanded with …

This study employed a ligand-based pharmacophoric approach to design and synthesize 33
novel semisynthetic labdane-appended triazolyl isatins to discover potential anti …