The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Covid‐19 vaccines and variants of concern: a review

I Hadj Hassine - Reviews in medical virology, 2022 - Wiley Online Library
Since the outbreak of coronavirus disease 2019 (Covid‐19) in December 2019, caused by
the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the number of …

Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study

P Naaber, L Tserel, K Kangro, E Sepp… - The Lancet Regional …, 2021 - thelancet.com
ABSTRACT Background SARS-CoV-2 mRNA vaccines have proven high efficacy, however,
limited data exists on the duration of immune responses and their relation to age and side …

Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study

OT Ranzani, MDT Hitchings, M Dorion, TL D'Agostini… - bmj, 2021 - bmj.com
Objective To estimate the effectiveness of the inactivated whole virus vaccine, CoronaVac
(Sinovac Biotech), against symptomatic covid-19 in the elderly population of São Paulo …

Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil

T Cerqueira-Silva, SV Katikireddi… - Nature Medicine, 2022 - nature.com
There is considerable interest in the waning of effectiveness of coronavirus disease 2019
(COVID-19) vaccines and vaccine effectiveness (VE) of booster doses. Using linked national …

Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control …

MDT Hitchings, OT Ranzani, MSS Torres… - The Lancet Regional …, 2021 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant,
Gamma, emerged in the city of Manaus in late 2020 during a large resurgence of …

Effectiveness of ChAdOx1 vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo

MDT Hitchings, OT Ranzani, M Dorion… - Nature …, 2021 - nature.com
A two-dose regimen of the Oxford-AstraZeneca (ChAdOx1) Covid-19 vaccine with an inter-
dose interval of three months has been implemented in many countries with restricted …

Impact of SARS-CoV-2 Gamma lineage introduction and COVID-19 vaccination on the epidemiological landscape of a Brazilian city

CA Banho, L Sacchetto, GRF Campos, C Bittar… - Communications …, 2022 - nature.com
Background: The emergence of the Brazilian variant of concern, Gamma lineage (P. 1),
impacted the epidemiological profile of COVID-19 cases due to its higher transmissibility …

Recognition of variants of concern by antibodies and T cells induced by a SARS-CoV-2 inactivated vaccine

F Melo-González, JA Soto, LA González… - Frontiers in …, 2021 - frontiersin.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus
responsible of the current pandemic ongoing all around the world. Since its discovery in …

SARS-CoV-2 infects adipose tissue in a fat depot-and viral lineage-dependent manner

TD Saccon, F Mousovich-Neto, RG Ludwig… - Nature …, 2022 - nature.com
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue
infection and disease progression has been proposed. Here we demonstrate that SARS …