Colorectal cancer (CRC) is one of the most common cancers in many parts of the world. Its
development is a multi-step process involving three distinct stages, initiation that alters the …

Background & aims Despite advances in chemotherapeutic agents and surgical approaches
for its management, gastrointestinal cancer still accounts for 27% of new cancer cases and …

Diet is an important risk factor for colorectal cancer (CRC), and several dietary constituents
implicated in CRC are modified by gut microbial metabolism. Microbial fermentation of …

Non-coding RNAs (ncRNAs) have been recognized as pivotal regulators of transcriptional
and post-transcriptional gene modulation, exerting a profound influence on a diverse array …

Omega 3 (n3) and Omega 6 (n6) polyunsaturated fatty acids (PUFAs) have been reported to
exhibit opposing roles in cancer progression. Our objective was to determine whether …

Combined intakes of specific dietary fiber and fat subtypes protect against colon cancer in
animal models. We evaluated associations between self-reported individual and …

Metabolic syndrome (MetS), a cluster of metabolic abnormalities composed of central
obesity, elevated blood pressure, glucose disturbances, hypercholesterolemia and …

Epigenetic aberrations have played a significant role in affecting the pathophysiological
state of colorectal cancer, and global DNA hypomethylation mainly occurs in partial …

Cancer cells are more susceptible to metabolic perturbations due to impaired electron
transport chain (ETC) that promote uncontrolled proliferation. Mitochondria play a pivotal …

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the world.
Multiple evidence suggests that there is an association between excess fat consumption and …