Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Aim Calcium ions play a pivotal role in matching energy supply and demand in cardiac
muscle. Mitochondrial calcium concentration is lower in animal models of heart failure with …

Cardiac muscle contraction is a strictly regulated process which conjugates a series of
electrophysiological, biochemical and mechanic events, resulting in the pum** of blood to …

The impaired ability of the heart to relax and stretch to accommodate venous return is
generally understood to represent a state of “diastolic dysfunction” and often described …

Nanodomains are intracellular foci which transduce signals between major cellular
compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) …

Right ventricular (RV) failure (RVF) has garnered significant attention in recent years
because of its negative impact on clinical outcomes in patients with pulmonary hypertension …

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vessel remodeling;
however, its severity and impact on survival depend on right ventricular (RV) failure …

Accurate measurement of cardiomyocyte contraction is a critical issue for scientists working
on cardiac physiology and physiopathology of diseases implying contraction impairment …

The effects of voluntary running on the skeletal muscle of rats with pulmonary arterial
hypertension (PAH) were tested in the present study. PAH was induced in rats by a single …