Novel and emerging treatments for major depression

S Marwaha, E Palmer, T Suppes, E Cons, AH Young… - The Lancet, 2023 - thelancet.com
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis

K Ko, EI Kopra, AJ Cleare, JJ Rucker - Journal of Affective Disorders, 2023 - Elsevier
Background Psychedelic therapy shows promise for Major Depressive Disorder, especially
when treatment-resistant, as well as life-threatening illness distress. The objective of this …

Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review

JJ Breeksema, BW Kuin, J Kamphuis… - Journal of …, 2022 - journals.sagepub.com
Introduction: Small-scale clinical studies with psychedelic drugs have shown promising
results for the treatment of several mental disorders. Before psychedelics become registered …

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

History repeating: guidelines to address common problems in psychedelic science

M van Elk, EI Fried - Therapeutic Advances in …, 2023 - journals.sagepub.com
Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …

Blinding and expectancy confounds in psychedelic randomized controlled trials

SD Muthukumaraswamy, A Forsyth… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: There is increasing interest in the potential for psychedelic drugs such as
psilocybin, LSD and ketamine to treat several mental health disorders, with a growing …

Psychedelics and psychedelic-assisted psychotherapy

CM Reiff, EE Richman, CB Nemeroff… - American Journal of …, 2020 - psychiatryonline.org
Objective: The authors provide an evidenced-based summary of the literature on the clinical
application of psychedelic drugs in psychiatric disorders. Methods: Searches of PubMed and …

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies

KAA Andersen, R Carhart‐Harris… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective To conduct a systematic review of modern‐era (post‐millennium) clinical studies
assessing the therapeutic effects of serotonergic psychedelics drugs for mental health …

Psychedelics promote structural and functional neural plasticity

C Ly, AC Greb, LP Cameron, JM Wong, EV Barragan… - Cell reports, 2018 - cell.com
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of
depression and related disorders. The ability to promote both structural and functional …

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

RL Carhart-Harris, M Bolstridge, CMJ Day, J Rucker… - …, 2018 - Springer
Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …