Id proteins are important parts of signaling pathways involved in development, cell cycle and
tumorigenesis. They were first shown to act as dominant negative antagonists of the basic …

Several major advances in the understanding of the regulation of vertebrate neurogenesis
by members of the basic helix-loop-helix (bHLH) protein family have been made in the past …

The mouse Mash-7 gene, like its Drosophila homologs of the achaete-scute complex (AS-
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …

Id proteins may control cell differentiation by interfering with DNA binding of transcription
factors. Here we show that targeted disruption of the dominant negative helix–loop–helix …

Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix
(HLH) factor that is thought to act as a negative regulator of neurogenesis. To directly …

GROWTH is one of the fundamental aspects in the development of an organism. Classical
genetic studies have isolated four viable, spontaneous mouse mutants1 disrupted in growth …

In the develo** mammalian central nervous system, neural precursor cells present in the
ventricular zone determine their fate to become neurons or glial cells, migrate towards the …

We show that when telencephalic neural progenitors are briefly exposed to bone
morphogenetic protein 2 (BMP2) in culture, their developmental fate is changed from …

We report the molecular characterization of a mouse basic helix-loop-helix factor,
designated MATH-1, structurally related to the product of the Drosophila proneural gene …

Molecular Interaction between transcription factors containing an baslc-hellx-loop-hellx
(bHLH) domain is known to regulate differentiation In several cellular systems Including …