Sažetak Studies with positive results are greatly more represented in literature than studies
with negative results, producing so-called publication bias. This review aims to discuss …

Background Large language models (LLMs) have the potential to support promising new
applications in health informatics. However, practical data on sample size considerations for …

METHODS Cross-sectional analysis of clinical trials enrolling participants< 18 years old
registered at ClinicalTrials. gov from October 2007 to March 2020. Multivariable logistic …

Objectives The purpose of this study was to conduct a methodological review of research on
the effects of conflicts of interest (COIs) in research contexts. Design Methodological review …

Background Rare diseases affect as many as 60 million people in the United States and
Europe. However, most rare diseases lack effective therapies and are in critical need of …

Background Ethical and scientific principles require that clinical trials address an important
question and have the resources needed to complete the study. However, there are no clear …

Aims Discontinuation or non‐publication of trials may hinder scientific progress and violates
the commitment made to research participants. We sought to identify the prevalence of …

Objectives Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive disorder.
Its predominant manifestations include exocrine pancreatic insufficiency, bone marrow …

Purpose To our knowledge, no study has quantified the rate of discontinuation and
nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity …

Background Despite the pivotal role of clinical trials in advancing orthopaedic oncology
knowledge and treatment strategies, the persistent issues of trial discontinuation and …