Integration of in vitro and in vivo models to predict cellular and tissue dosimetry of nanomaterials using physiologically based pharmacokinetic modeling
Nanomaterials (NMs) have been increasingly used in a number of areas, including
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …
Cellular targets and mechanisms in the cytotoxic action of non-biodegradable engineered nanoparticles
E Frohlich - Current drug metabolism, 2013 - ingentaconnect.com
The use of nanoparticles (NPs) has improved the quality of many industrial, pharmaceutical,
and medical products. Increased surface reactivity, a major reason for the positive effects of …
and medical products. Increased surface reactivity, a major reason for the positive effects of …
Estimating the effective density of engineered nanomaterials for in vitro dosimetry
G DeLoid, JM Cohen, T Darrah, R Derk… - Nature …, 2014 - nature.com
The need for accurate in vitro dosimetry remains a major obstacle to the development of cost-
effective toxicological screening methods for engineered nanomaterials. An important key to …
effective toxicological screening methods for engineered nanomaterials. An important key to …
An integrated approach for the in vitro dosimetry of engineered nanomaterials
Background There is a great need for screening tools capable of rapidly assessing
nanomaterial toxicity. One impediment to the development of reliable in vitro screening …
nanomaterial toxicity. One impediment to the development of reliable in vitro screening …
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than …
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres
such as asbestos. It is important to test this hypothesis to ascertain safe methods for CNT …
such as asbestos. It is important to test this hypothesis to ascertain safe methods for CNT …
The effects of nanoparticles on the renal system
Through a process of translocation across biological barriers, nanoparticles can reach and
deposit in secondary target organs where they may induce adverse biological reactions …
deposit in secondary target organs where they may induce adverse biological reactions …
Nanoparticle administration method in cell culture alters particle-cell interaction
TL Moore, DA Urban, L Rodriguez-Lorenzo… - Scientific reports, 2019 - nature.com
As a highly interdisciplinary field, working with nanoparticles in a biomedical context
requires a robust understanding of soft matter physics, colloidal behaviors, nano …
requires a robust understanding of soft matter physics, colloidal behaviors, nano …
At the Crossroads of Nanotoxicology in vitro: Past Achievements and Current Challenges
SM Hussain, DB Warheit, SP Ng… - Toxicological …, 2015 - academic.oup.com
The exponential growth in the employment of nanomaterials (NMs) has given rise to the field
of nanotoxicology; which evaluates the safety of engineered NMs. Initial nanotoxicological …
of nanotoxicology; which evaluates the safety of engineered NMs. Initial nanotoxicological …
ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systems
Background The development of particokinetic models describing the delivery of insoluble
or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis …
or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis …
A Critical Review of in Vitro Dosimetry for Engineered Nanomaterials
JM Cohen, GM DeLoid, P Demokritou - Nanomedicine, 2015 - Taylor & Francis
A major obstacle in the development of accurate cellular models for investigating nanobio
interactions in vitro is determination of physiologically relevant measures of dose …
interactions in vitro is determination of physiologically relevant measures of dose …