Phage choice, isolation, and preparation for phage therapy
Phage therapy is the use of bacteriophages—viruses that use bacteria as their host cells—
as biocontrol agents of bacteria. Currently, phage therapy is garnering renewed interest as …
as biocontrol agents of bacteria. Currently, phage therapy is garnering renewed interest as …
The factors affecting effectiveness of treatment in phages therapy
MH Ly-Chatain - Frontiers in microbiology, 2014 - frontiersin.org
In recent years, the use of lytic bacteriophages as antimicrobial agents controlling
pathogenic bacteria has appeared as a promising new alternative strategy in the face of …
pathogenic bacteria has appeared as a promising new alternative strategy in the face of …
Systematic discovery of antiphage defense systems in the microbial pangenome
INTRODUCTION Bacteria and archaea are frequently attacked by viruses (phages) and as a
result have developed multiple, sophisticated lines of active defense that can collectively be …
result have developed multiple, sophisticated lines of active defense that can collectively be …
Prokaryotic viperins produce diverse antiviral molecules
Viperin is an interferon-induced cellular protein that is conserved in animals. It has
previously been shown to inhibit the replication of multiple viruses by producing the …
previously been shown to inhibit the replication of multiple viruses by producing the …
Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types
To provide protection against viral infection and limit the uptake of mobile genetic elements,
bacteria and archaea have evolved many diverse defence systems. The discovery and …
bacteria and archaea have evolved many diverse defence systems. The discovery and …
DISARM is a widespread bacterial defence system with broad anti-phage activities
The evolutionary pressure imposed by phage predation on bacteria and archaea has
resulted in the development of effective anti-phage defence mechanisms, including …
resulted in the development of effective anti-phage defence mechanisms, including …
Bacteriophage procurement for therapeutic purposes
B Weber-Dąbrowska, E Jończyk-Matysiak… - Frontiers in …, 2016 - frontiersin.org
Bacteriophages (phages), discovered 100 years ago, are able to infect and destroy only
bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a …
bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a …
Factors determining phage stability/activity: challenges in practical phage application
E Jończyk-Matysiak, N Łodej, D Kula… - Expert review of anti …, 2019 - Taylor & Francis
Introduction: Phages consist of nucleic acids and proteins that may lose their activity under
different physico-chemical conditions. The production process of phage formulations may …
different physico-chemical conditions. The production process of phage formulations may …
Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode
To withstand their internal turgor pressure and external threats, most bacteria have a
protective peptidoglycan (PG) cell wall. The growth of this PG polymer relies on autolysins …
protective peptidoglycan (PG) cell wall. The growth of this PG polymer relies on autolysins …
Bacteriophage therapy: advances in formulation strategies and human clinical trials
D Vandenheuvel, R Lavigne… - Annual review of …, 2015 - annualreviews.org
Recently, a number of phage therapy phase I and II safety trials have been concluded,
showing no notable safety concerns associated with the use of phage. Though hurdles for …
showing no notable safety concerns associated with the use of phage. Though hurdles for …