Drug repositioning: current approaches and their implications in the precision medicine era
A Talevi - Expert Review of Precision Medicine and Drug …, 2018 - Taylor & Francis
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It
represents a cost-efficient approach, since the new indications are built on the basis of …
represents a cost-efficient approach, since the new indications are built on the basis of …
Targeting human Glucokinase for the treatment of type 2 diabetes: an overview of allosteric Glucokinase activators
Diabetes mellitus is a worldwide impacting disorder and the ratio through which the number
of diabetic patients had increased worldwide, puts medical professionals to serious stress …
of diabetic patients had increased worldwide, puts medical professionals to serious stress …
Recent developments in medicinal chemistry of allosteric activators of human glucokinase for type 2 diabetes mellitus therapeutics
Background: Glucokinase (GK), a cytoplasmic enzyme catalyzes the metabolism of glucose
to glucose-6-phosphate with the help of ATP and aids in the controlling of blood glucose …
to glucose-6-phosphate with the help of ATP and aids in the controlling of blood glucose …
Drug-target interactions: prediction methods and applications
Identifying the interactions between drugs and target proteins is a key step in drug discovery.
This not only aids to understand the disease mechanism, but also helps to identify …
This not only aids to understand the disease mechanism, but also helps to identify …
Structure based virtual screening of natural compounds and molecular dynamics simulation: Butirosin as Dipeptidyl peptidase (DPP-IV) inhibitor
Type II diabetes mellitus (T2DM) is a major metabolic disorder resulting in increase in
morbidity and mortality rates. Dipeptidyl peptidase-IV (DPP-IV) is a validated and interesting …
morbidity and mortality rates. Dipeptidyl peptidase-IV (DPP-IV) is a validated and interesting …
Research into how carvacrol and metformin affect several human proteins in a hyperglycemic condition: A comparative study in silico and in vitro
Carvacrol (CV) is an organic compound found in the essential oils of many aromatic herbs. It
is nearly unfeasible to analyze all the current human proteins for a query ligand using in vitro …
is nearly unfeasible to analyze all the current human proteins for a query ligand using in vitro …
Structural insight into the glucokinase-ligands interactions. Molecular docking study
E Ermakova - Computational biology and chemistry, 2016 - Elsevier
Glucokinase (GK) plays a key role in the regulation of hepatic glucose metabolism.
Inactivation of GK is associated with diabetes, and an increase of its activity is linked to …
Inactivation of GK is associated with diabetes, and an increase of its activity is linked to …
Design, synthesis, molecular docking and in vitro biological evaluation of benzamide derivatives as novel glucokinase activators
AA Kazi, VA Chatpalliwar - Current Enzyme Inhibition, 2022 - ingentaconnect.com
Background: Glucokinase (GK) is a cytoplasmic enzyme that metabolizes glucose to glucose-
6-phosphate and supports adjusting blood glucose levels within the normal range in …
6-phosphate and supports adjusting blood glucose levels within the normal range in …
[CITATION][C] 桑叶总黄酮对 2 型糖尿病模型大鼠肝脏的保护作用
谭林， 刘冬恋， 杨春梅， 杨霞， 游均梅， 牟倩云 - 食品工业科技, 2016