Mitochondrial protein transport: Versatility of translocases and mechanisms
Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …
Mitochondrial quality control in health and in Parkinson's disease
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …
pivotal organelle, dysfunction of which has been linked to several human diseases including …
Detecting sequence signals in targeting peptides using deep learning
In bioinformatics, machine learning methods have been used to predict features embedded
in the sequences. In contrast to what is generally assumed, machine learning approaches …
in the sequences. In contrast to what is generally assumed, machine learning approaches …
Quality control of the mitochondrial proteome
Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …
Mitochondrial proteins: from biogenesis to functional networks
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …
functions in bioenergetics, metabolism and signalling and have been associated with …
The multiple links between actin and mitochondria
Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …
confounded by the overlap of multiple actin-based structures in space and time. Here, we …
Mitochondrial membrane potential
The mitochondrial membrane potential (ΔΨm) generated by proton pumps (Complexes I, III
and IV) is an essential component in the process of energy storage during oxidative …
and IV) is an essential component in the process of energy storage during oxidative …
The role of glutathione reductase and related enzymes on cellular redox homoeostasis network
In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …
Central role of Tim17 in mitochondrial presequence protein translocation
LF Fielden, JD Busch, SG Merkt, I Ganesan, C Steiert… - Nature, 2023 - nature.com
The presequence translocase of the mitochondrial inner membrane (TIM23) represents the
major route for the import of nuclear-encoded proteins into mitochondria,. About 60% of …
major route for the import of nuclear-encoded proteins into mitochondria,. About 60% of …
Mitochondrial machineries for protein import and assembly
Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …