The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane …

Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are
activated by ligand-induced conformational changes. We quantified the dimerization of three …

Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic
stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis …

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive
production of mature blood cells. In the majority of classic MPN—polycythemia vera …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal
myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of …

Mutations in signaling molecules of the cytokine receptor axis play a central role in
myeloproliferative neoplasm (MPN) pathogenesis. Polycythemia vera is mainly related to …

A well-functioning hematopoietic system requires a certain robustness and flexibility to
maintain appropriate quantities of functional mature blood cells, such as red blood cells and …

Our understanding of the genetic basis of the Philadelphia chromosome-negative
myeloproliferative neoplasms (MPNs) has moved forward at a staggering pace over the last …