Multi-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer

C Corradi, M Gentiluomo, V Adsay, J Sainz… - Seminars in Cancer …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of
pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed …

Physical activity, sedentary behavior, and pancreatic cancer risk: a mendelian randomization study

M Gentiluomo, SC Dixon-Suen… - Journal of the …, 2024 - academic.oup.com
Pancreatic cancer is currently the seventh leading cause of cancer death worldwide.
Understanding whether modifiable factors increase or decrease the risk of this disease is …

Explainable machine learning identifies a polygenic risk score as a key predictor of pancreatic cancer risk in the UK Biobank

G Peduzzi, A Felici, R Pellungrini, D Campa - Digestive and Liver Disease, 2024 - Elsevier
Background Predicting the risk of develo** pancreatic ductal adenocarcinoma (PDAC) is
of paramount importance, given its high mortality rate. Current PDAC risk prediction models …

Association of Smoking with progression from low-risk to high-risk intraductal papillary mucinous neoplasms and pancreatic cancer

G Lauri, L Apadula, L Archibugi, P Lazzano… - Digestive and Liver …, 2025 - Elsevier
Background Factors associated with the risk of pancreatic adenocarcinoma (PDAC) may
play a role in the development and progression of Intraductal Papillary Mucinous …

Upregulation of Lactobacillus spp. in gut microbiota as a novel mechanism for environmental eustress-induced anti-pancreatic cancer effects

Y Liang, M Du, X Li, J Gao, Q Li, H Li, J Li, X Gao… - Gut …, 2025 - Taylor & Francis
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited
effective treatment options. Emerging evidence links enriched environment (EE)-induced …

Polymorphisms within autophagy‐related genes as susceptibility biomarkers for pancreatic cancer: A meta‐analysis of three large European cohorts and functional …

F Gálvez‐Montosa, G Peduzzi… - … journal of cancer, 2025 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients
having unresectable or metastatic disease at diagnosis, with poor prognosis and very short …

A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma

M Giaccherini, M Rende, M Gentiluomo, C Corradi… - …, 2024 - academic.oup.com
Pleiotropic variants (ie genetic polymorphisms influencing more than one phenotype) are
often associated with cancer risk. A scan of pleiotropic variants was successfully conducted …

Comment on:“Analysis of exposome and genetic variability suggests stress as a major contributor for development of pancreatic ductal adenocarcinoma”

A Advani, K Deewan, A Odhwani… - Digestive and Liver …, 2024 - dldjournalonline.com
We have extensively reviewed the paper “Analysis of exposome and genetic variability
suggests stress as a major contributor for development of pancreatic ductal …

Author's Reply: Comment on “Analysis of exposome and genetic variability suggests stress as a major contributor for development of pancreatic ductal …

G Peduzzi, A Felici, R Pellungrini… - Digestive and Liver …, 2025 - dldjournalonline.com
We acknowledge the time and effort that Advani A. and colleagues have spent in reading
our paper, by Peduzzi et al.[1], and we thank them for their appreciation. The authors raised …

Early-onset cancers and exposome paradigm: A global perspective with a focus on India

K Shridhar, R Nagrani - Annals of Oncology Research and …, 2024 - journals.lww.com
Early-onset cancers (EOCs) are the cancers diagnosed in adults between 20 and 49 years
of age. Globally, 14 cancer types including cancers in the breast, colorectum, endometrium …