Immunomodulatory action of Lactococcus lactis

LAK Saleena, MYM Teo, YH How, LLA In… - Journal of bioscience and …, 2023 - Elsevier
Highlights•Superior biological activities of different Lactococcus lactis strains.•Upregulation
of innate and specialised immune responses in all compartments.•Several potential health …

Freeze drying of food-grade recombinant Lactococcus lactis NZ3900-fermented milk with different protecting agents

YH How, MYM Teo, LLA In, SK Yeo, B Bhandari… - International Dairy …, 2023 - Elsevier
Lactococcus lactis NZ3900 expressing K-ras mimotope as a live vaccine is a promising non-
invasive form of targeted immunotherapy for K-ras-mutated colorectal cancers. However, the …

Recombinant lactococcal-based oral vaccine for protection against Streptococcus agalactiae infections in tilapia (Oreochromis niloticus)

KY Wong, MHMM Khair, AAL Song… - Fish & Shellfish …, 2024 - Elsevier
Streptococcosis outbreaks caused by Streptococcus agalactiae infection in tilapia
aquaculture have been consistently reported and associated with high mortality and …

Stability and expression of K-ras mimotopes in freeze-dried recombinant Lactococcus lactis NZ3900-fermented milk powder during storage in vacuum packaging

YH How, MYM Teo, LLA In, SK Yeo… - Journal of Applied …, 2024 - academic.oup.com
Aims This study aims to evaluate the storage stability of the freeze-dried recombinant
Lactococcus lactis NZ3900-fermented milk powder expressing K-ras (Kristen rat sarcoma …

[HTML][HTML] Adenovirus-mediated expression of MOAP-1, Bax and RASSF1A antagonizes chemo-drug resistance of human breast cancer cells expressing cancer stem …

EW Tan, ADI Abdullah, LC Ming, CL Poh… - Biomedicine & …, 2024 - Elsevier
Cancer is one of the major leading causes of mortality globally and chemo-drug-resistant
cancers pose significant challenges to cancer treatment by reducing patient survival rates …

[HTML][HTML] Development of fermented milk using food-grade recombinant Lactococcus lactis NZ3900

YH How, MYM Teo, LLA In, SK Yeo, LP Pui - NFS Journal, 2022 - Elsevier
Fermented milk has been associated with the improvement of human health for decades.
Food-grade Lactococcus lactis NZ3900 is a potential host for producing and delivering …

Effect of Secretion Efficiency of Mutant KRAS Neoantigen by Lactococcus lactis on the Immune Response of a Mucosal Vaccine Delivery Vehicle Targeting Colorectal …

NAR Alias, WPY Hoo, PY Siak, SS Othman… - International Journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is often caused by mutations in the KRAS oncogene, making KRAS
neoantigens a promising vaccine candidate for immunotherapy. Secreting KRAS antigens …

Storage stability of food-grade recombinant Lactococcus lactis NZ3900-fermented milk expressing K-ras mimotopes

YH How, MYM Teo, LLA In, SK Yeo, B Bhandari… - Journal of Food …, 2024 - Springer
K-ras mimotope expressed by Lactococcus lactis NZ3900 is a potential live oral vaccine
developed to target specific K-ras mutations in colorectal cancer. However, the storage and …

Development of therapeutic or prophylactic recombinant Lactococcus lactis NZ9000-fermented milk with KRAS mimotope

SY Tan, YH How, PY Siak, LP Pui, LLA In - Food Biotechnology, 2022 - Taylor & Francis
Milk is a common carrier for live cultures due to its abundant nutrients. Accumulating
evidence has shown the efficacy of live culture as a vector to deliver drugs. This study aimed …