Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases resulting in hypoxia. Sustained …

Bronchopulmonary dysplasia and emphysema are significant global health problems at the
extreme stages of life. Both are characterized by arrested alveolar development or loss of …

During late lung development, alveolar and microvascular development is finalized to
enable sufficient gas exchange. Impaired late lung development manifests as …

Background—The cause of pulmonary arterial hypertension (PAH) was investigated in
humans and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain …

Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

Interest in the contribution of changes in lung development during early life to subsequent
respiratory morbidity is increasing. Most evidence of an association between adverse …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Rationale: Bronchopulmonary dysplasia (BPD) and emphysema are characterized by
arrested alveolar development or loss of alveoli; both are significant global health problems …

Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

Increasing evidence indicates that bronchopulmonary dysplasia (BPD) results, at least in
part, from an imbalance between pro-inflammatory and anti-inflammatory mechanisms, with …